New class of cancer drugs down, not out, after Roche trial setback - analysts
By
Roche said an interim analysis of an ongoing clinical trial showed that its experimental drug, tiragolumab, failed to meaningfully slow disease progression in newly diagnosed patients with advanced non-small-cell lung cancer (NSCLC) in combination with its approved PD-L1 immunotherapy Tecentriq, versus Tecentriq alone.
The study will continue to evaluate whether the combination helps patients live longer, the gold standard for cancer treatments.
The news comes after the Swiss drugmaker disclosed in March tiragolumab had failed to slow progression of a rarer, more aggressive form of lung cancer.
Analysts had assigned a higher likelihood of success to the NSCLC trial, since it included patients with the most common form of lung cancer with high levels of PD-L1 proteins targeted by Tecentriq.
This emerging class of so-called anti-TIGIT therapies has already triggered a flurry of research and deal activity, including by Gilead Sciences (GILD), Merck & Co (MRK) and GSK. Drugmakers are looking to nab a piece of the lucrative cancer market focused on a protein believed to help cancer cells thwart immune system detection.
Roche shares fell almost 7% on Wednesday for its worst day
since
"We see this failure as bad for the sector in general,"
Truist Securities analyst
But she noted that for many immuno-oncology studies, much of the difference in results has been seen in overall survival benefit, rather than keeping the disease from worsening, known as progression-free survival.
The global cancer drug market is expected to balloon to
Chemotherapy and other targeted medicines are commonly used to bolster the effects of immunotherapies, such as the established PD-L1 and PD-1 checkpoint inhibitors such as Merck's (MRK) top-selling Keytruda. The fresh hope is that targeting two checkpoint proteins - TIGIT and PD-L1/PD-1 - will better treat a broader set of patients.
The Roche news follows the sting of a string of prominent immunotherapy combination failures in recent years.
RBC Capital Markets' analyst
The disappointing result from the Roche trial is likely to cast doubt on whether the TIGIT class has additive efficacy in oncology, but clearer benefits could be achieved with a different drug/construct, he added.
The setback on Wednesday could also be linked to the way Roche designed a statistical plan for the trial, analysts cautioned, suggesting that the study still had a chance of eventually demonstrating positive results.
Evercore ISI analysts put out a note on Wednesday headlined: "I do NOT think TIGIT failed."
(Reporting by